Royan Institute is a public non-profitable organization which is affiliated to Academic Center for Education, Culture and Research (ACECR) and was established in 1991 by the late Dr. Saeid Kazemi Ashtiani as a research institute for Reproductive Biomedicine and infertility treatments. In 1998 this institute was approved by Ministry of Health as Cell Based Research Center. Now this institute acts as leader of Stem Cell research and also one of the best clinics for infertility treatment. It has 46 scientific members and 186 lab technicians. Royan consists of three research institutes, each focused on different fields of research:

  • Royan Institute for Stem Cell Biology and Technology (RI-SCBT)
  • Royan Institute for Reproductive Biomedicine (RI-RB)
  • Royan Institute for Animal Biotechnology (RI-AB)

A Chronological Overview of the Institute Developments

  • The first IVF birth in Tehran (1993)
  • The second ICSI birth in Iran (1995)
  • Iran second success in open testicular biopsy to treat severe male infertility (1996)
  • The first frozen embryo birth in Iran (1996)
  • The first ICSI birth by frozen sperm of a gonadectomized man (1999)
  • The first celebration of the 1000th birth by the assisted conception treatment in Iran (1999)
  • The first human embryonic Stem Cell line establishment in Iran and the region (2003)
  • Establishment of Stem Cells research department (2003)
  • The first PGD child born in Iran (2004)
  • The first time use of Adult Stem Cell in treatment of MI during CABG in Iran (2004)
  • Production of Insulin Producing Cells from Human Embryonic Stem Cells (2004)
  • Culture of Human Limbal Stem Cells on Chorionic Membrane and use them for corneal injuries (2004)
  • Establishment of the first Private Cord Blood Bank in Iran (2005)
  • The first IVM-IVF sheep born in Iran (2006)
  • The first cloned sheep born in Iran (2006)
  • The first nuclear transferred, in vitro fertilizied sheep born (2006)
  • Culture and transplantation of fibroblasts (2007)
  • Establishment of mouse and human induced pluripotent stem cells (iPS) (2008)
  • Transplantation of melanocytes for patient with vitiligo (2008)
  • The first cloned goat born in Iran (2009)
  • The first transgenic goats born in Iran (2010)
  • The first calves born from vitrified in vitro developed embryos in Iran (2011)
  • Establishment of cell therapy pre-hospital (2011)
  • Establishment of Stem Cell Bank (2011)
  • The first healthy child birth after Molecular PGD for beta-thalassemia in Iran (2012)
  • Birth of eight cloned goats through the simplified method of SCNT in Iran (2013) 

Prominent Achievements

  • Report of three new mutation of cystic fibrosis
  • Best paper selection in MEFS congress 2004
  • Second place of Razi medical science award 2003
  • Best young researcher in Razi medical science award 2004
  • Report of human embryonic stem cells’ proteomics for the first time in the world
  • Registration of one human embryonic stem cell line in International Society of Stem Cell Research
  • Establishment of 6 human embryonic stem cell lines
  • Establishment of 8 mouse embryonic stem cell lines which three of them can be donated to the centers or researchers for one time
  • Introduction of late director of Royan Institute as Iran’s everlasting legend in 2005
  • Best poster award in Stem Cell congress, India, 2005
  • Selection as “prominent research center” in Razi medical sciences award
  • Best researcher in Razi medical sciences award 2006
  • Best medical journal (Cell Journal(yakhteh) ) in Razi medical sciences award 2006
  • Best research achievement prize in Razi medical sciences award
  • Best research achievement prize in Kharazmi young researcher award 2006
  • Best research prize in second international reproduction student award, Yazd, Iran, 2007
  • Report of Mesenchymal stem cells’ new surface markers to the world
  • Publication of 626 papers in local and international journals
  • Performance of 341 research project and follow of 225 undergoing projects
  • Presentation of 997 papers in national and international congresses
  • Publication of two journals: Cell Journal(Yakhteh)and IJFS (Iranian Journal of Fertility and Sterility), Indexed in ISI
  • Editorial board of four internationals
  • six chapters of international textbooks in stem cell fields
  • Publication of 21 books
  • Performance of more than 56 inter-center and multi-center research nationally or internationally
  • Use of adult stem cells in corneal injuries and myocardial infarction on human
  • Transplantation of stem cells to the animal model of diseases in hepatic cirrhosis, spinal cord injuries, bone defects, cartilage damages and diabetes
  • Several research achievements in preimplantation diagnosis and screening
  • Producing iPS cell line, Royan H7
  • Registration of T338A, K536X, Y122H genes in CBAVD (Congenital Bilateral Absence of Vas Deferens) patients, 2007


  • Cell Therapy Center 

Branch of biological science that was first introduced by Trembly, which caused many ofthe cognitions in the development and revolution in medical treatment, suggested to cure the cause of disease rather than treating their symptoms. Regenerative Medicine is a collection of applied data from biology, such as growth factors, cell therapy, tissue engineering and organ transplantation with the aim of reducing tissue destructionrelated mortality. Currently in spite of advances in identification of growth factors involved in the normal regeneration of the body or improvement in tissue engineering and organ transplantation, cell therapy with the simple idea of replacing the missing parts by using stem cells is still the best choice. As a result most of the research activities conducted at the Department of Regenerative Medicine focused on translational and clinical studies using cell therapy.Clinical use of cell therapy requires provision of specific infrastructure constructions. One of them is providing GMP condition for cell production. In these units, as well as isolation and culturing cells in completely sterile conditions, plenty of efforts are made to produce cells with highest quality for cell therapy. Therefore, quality control laboratories in addition to clean rooms are important parts of this unit. Translating the results obtained from studies in animal models is another feature of this group. In this regard, model of acute renal failure with use of cyclosporine and kidney transplantation in monkeys was set in 2012. Besides the above-mentioned potential, the active research groups in the department include:

  • Skin disorders
  • Cardiovascular disorders
  • Bone and Joint disorders
  • Neuromuscular disorders
  • Kidney disorders
  • Infertility Clinic

An estimated about 10-15% of couples suffer from infertility, and cannot conceive a child on their own.
Royan Infertility Clinic is nationally and internationally recognized for its advanced reproductive treatments and consistently superior birthrate success.
Since its inception in 1991, the center has focused on introducing and perfecting new procedures and techniques that are at the forefront of reproductive technology including IUI, Ovulation Induction, IVF, ICSI, PGD, PESA/TESE, Cryopreservation and Assisted Hatching. 
As a result of the center’s expert interventions and exceptional and experienced group of physicians, infertility specialists, and clinical and laboratory experts, several thousand babies have been born to happy parents across the Iran and around the world.